Development Of Drugs With High Potency And Inhibitory...

Summary of research plan Development of drugs with high potency and inhibitory activity against specific activating mutation, while showing significantly less activity against wild type mutations, made testing specific sensitizing mutation necessary. (1) (EGFR) T790M mutation a successful example of a biomarker for non-small cell lung cancer (NSCLC) treatment with Osimertinib that gained a wide acceptance in clinical practice in Europe and US (), One question that needs to be asked, however, is whether testing for similar mutations in different cancer will be of clinical value. an unknown subpopulation of patients with CRC will have an activating EGFR mutation, such as L858R, which is thought to activate the receptor constitutively, regardless of ligand status promoting cellular proliferation and growth. in patients with colorectal cancer, Targeting activated EGFR, hypothetically, will lead to growth inhibition of cancer cell dependent on the oncogenic drive of sensitising EGFR mutation. This project aims t o investigate the role of EGFR (L858R/+/+) as a biomarker for AZD 9291 (Osimertinib) treatment, using SW48 cell line with a wild type mutation of EGFR and Heterozygous knockin of EGFR activating mutation (L858R/+/+), to investigate the mechanism of resistances if cells developed resistance and to test the overlap between Osimertinib and AZD5363, palbocidib and selumetinib. This work should improve treatment outcome for patients with CRC with EGFR sensitising mutationShow MoreRelatedThe Consequences Of The Discovery Of Pi3k Inhibitors791 Words   |  4 Pagesunder way. There is evidence that the early compounds namely quercetin, wortmannin and LY294002 could inhibit PI3K pathway. The latter two compounds were able to rule the research for more than a decade but their high toxicity and insolubility precludedthem as in vivo pharmacological drugs [Falasca (2010]. 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